反应详情

21.2 g (0.083 mol) of 4-chloro-6,7,8-trimethoxyquinazoline, 17.0 g (0.112 mol) of piperonylamine and 13.5 g (0.127 mol) of sodium carbonate were mixed with 400 ml of isopropyl alcohol. The obtained mixture was heated under reflux for 24 hours and distilled under a reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (ethyl acetate) and recrystallized from ethyl acetate to give 21.3 g of the title compound as a pale-yellow needle.

1. temperatureThe obtained mixture was heated
2. temperatureunder reflux for 24 hours
3. distillationdistilled under a reduced pressure
4. customto remove the solvent
5. customThe residue was purified by silica gel column chromatography (ethyl acetate)
6. customrecrystallized from ethyl acetate