Pyridine → 4-(3-Methanesulfonylamino-4-chlorobenzyl)amino-6-chloroquinazoline

HRID 2392878Notes

Reaction equation

HRID 2392878 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][C:7]1[CH:8]=[C:9]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:10][NH:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([Cl:22])[CH:20]=2)[N:15]=[CH:14][N:13]=1.N1C=CC=CC=1>O>[CH3:1][S:2]([NH:6][C:7]1[CH:8]=[C:9]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:10][NH:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([Cl:22])[CH:20]=2)[N:15]=[CH:14][N:13]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 187967134-(3-Amino-4-chlorobenzyl)amino-6-chloroquinazoline

Product 1

HCID 187966724-(3-Methanesulfonylamino-4-chlorobenzyl)amino-6-chloroquinazoline

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

75 μl of methanesulfonyl chloride was added to a mixture comprising 100 mg of 4-(3-amino-4-chlorobenzyl)amino-6-chloroquinazoline and 3 ml of pyridine. The obtained mixture was stirred at room temperature for 1.5 hours. 20 ml of water was added in portions to the reaction mixture to precipitate crystals. The crystals were recovered by filtration, washed with water and dried to give 109 mg of the title compound.

Workup

  1. customto precipitate crystals
  2. filtrationThe crystals were recovered by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-f32d2d560df841cfbdb530034f843669
Source dataset
uspto-grants-1998_09
Patent number
US05801180

Reaction notes

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