反应详情

2.0 g of 2,6-dichloro-4-(3,4-methylenedioxybenzyl)aminoquinazoline was heated to 120° C. in 50 ml of ethanolic ammonia put in a pressure vessel for 18 hours, cooled and concentrated under a reduced pressure. The obtained residue was introduced to a silica gel column and eluted with a chloroform/methanol (9:1) mixture to give 830 mg of the title compound.

1. temperaturecooled
2. concentrationconcentrated under a reduced pressure
3. additionThe obtained residue was introduced to a silica gel column
4. washeluted with a chloroform/methanol (9:1) mixture