Ethanol → HCID 18980720, compound

Participants

Reaction Conditions

Reaction Steps

A reactor was charged with 18.6 g (0.04 mole) of 13-butyl-11,15-dihydroxy-9,13,17-triazapentacosane, 100 g of ethanol and 50 g of water, and the contents were heated to 70° C. Thereafter, an aqueous solution of 43 g (0.37 mole) of sodium chloroacetate was added to the contents. The resultant mixture was kept at pH 9 and stirred for 20 hours. After completion of the reaction, ethanol was distilled off under reduced pressure, and the residue was diluted to 10% with water. The resulting solution was adjusted to pH 7, desalted by electrodialysis and lyophilized, thereby obtaining 20.2 g (isolation yield: 85%) of 6-butyl-4,8-dihydroxy-2,10-dioctyl-2,6,10-triaza-1,11-undecanedicarboxylic acid.

Provenance & Evidence