Hydrochloric Acid → HCID 18980743, compound

Participants

Reaction Steps

The same procedures as in Example 26 were performed except that 1 g (2.75 mmol) of methyl 7-(N-t-butoxycarbonylamino)-3-oxo-2-phenylheptanoate instead of ethyl 7-(N-t-butoxycarbonylamino)-3-oxo-2-phenylheptanoate was dissolved in 6 ml of methanol, 104 mg (2.75 mol) of sodium borohydride was added, and 5 ml of 4N hydrochloric acid was added to the reaction solution, to prepare the target compound as a pale yellow oil in an amount of 0.9 g at a yield of 90.0%. The products were analyzed to result in that the ratio of the syn-form to the anti-form was 9:1. The analytical results on the target compound are given below.

Provenance & Evidence