Sodium Hydroxide → HCID 9929026, compound

Participants

Reaction Steps

1.32 g of (2E,4E)-3-Methyl-5-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopent-1-enyl]-penta-2,4-dienoic acid ethyl ester was dissolved in 13 ml of THF/EtOH=1/1 and treated with 5.6 ml of 3N NaOH. The mixture was kept for 48 h at ambient temperature and then poured onto crushed ice/HCI. Extraction with AcOEt, washing with H2O, drying over Na2 SO4, evaporation of the solvent, and recrystallization from AcOEt afforded 803 mg of the title compound as yellow crystals of mp. 195°-196°(dec.).

Provenance & Evidence