反应详情

The ethyl (1-phenylethyl)malonate is stirred overnight with sodium hydroxide (1.3 eq) in an acetone/water (3:1 by volume) mixture. After concentrating to dryness, the residue is taken up with water (40 mL) and the mixture is then extracted three times with ethyl acetate (25 mL). The organic phase is washed, dried, filtered and concentrated to dryness to yield 3.5 g of 2-ethoxycarbonyl-3-phenylbutanoic acid in a 65% yield in the form of an oil, having the following characteristics: Rf =0.50 [methylene chloride/methanol (9:1 by volume)].

1. concentrationAfter concentrating to dryness
2. extractionthe mixture is then extracted three times with ethyl acetate (25 mL)
3. washThe organic phase is washed
4. customdried
5. filtrationfiltered
6. concentrationconcentrated to dryness