HuagongsheHuagongshe Chemistry Print Report · For research reference only
benzyl (2S)-2-aminopropanoate → N-(2-acetylthiomethyl-1-oxo-3-phenylbutyl)alanine benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | benzyl (2S)-2-aminopropanoate | HCID 726858 | — |
| Reactant | 2-Acetylthiomethyl-3-phenylbutanoic acid | HCID 10060778 | — |
| Product | N-(2-acetylthiomethyl-1-oxo-3-phenylbutyl)alanine benzyl ester | HCID 10409503 | 68% |
Reaction Steps
Using the procedure described in Example 60, starting with 2-acetylthiomethyl-3-phenylbutanoic acid and alanine benzyl ester, and after purification by chromatography, eluting with a cyclohexane/ethyl acetate (75:25 by volume) mixture, N-(2-acetylthiomethyl-1-oxo-3-phenylbutyl)alanine benzyl ester is obtained in a 68% yield, the characteristics of which are as follows: Rf =0.31 [hexane/ethyl acetate (75:25 by volume)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05801274 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-7fdac57c71f54fd7b607a100f8d01ecb |
| Source note | uspto-grants-1998_09 |