HuagongsheHuagongshe Chemistry Print Report · For research reference only
benzyl (2S)-2-aminopropanoate → N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]alanine benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | benzyl (2S)-2-aminopropanoate | HCID 726858 | — |
| Reactant | 2-Acetylthiomethyl-3-(4-hydroxyphenyl)butanoic acid | HCID 18980788 | — |
| Product | N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]alanine benzyl ester | HCID 54412918 | 69% |
Reaction Steps
Using the procedure described in Example 60, but starting with 2-acetylthiomethyl-3-(4-hydroxyphenyl)butanoic acid and alanine benzyl ester, N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]alanine benzyl ester is obtained in a 69% yield, the characteristics of which are as follows: Rf =0.22 [hexane/ethyl acetate (65:35 by volume)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05801274 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-486bad81c00f41558207d264e4def236 |
| Source note | uspto-grants-1998_09 |