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(S)-Benzyl 2-amino-3-(4-hydroxyphenyl)propanoate → N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]tyrosine benzyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (S)-Benzyl 2-amino-3-(4-hydroxyphenyl)propanoate | HCID 104541 | — |
| 反応物 | 2-Acetylthiomethyl-3-(4-hydroxyphenyl)butanoic acid | HCID 18980788 | — |
| 生成物 | N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]tyrosine benzyl ester | HCID 10075398 | 78% |
反応手順
Using the procedure described in Example 60, but starting with 2-acetylthiomethyl-3-(4-hydroxyphenyl)butanoic acid and tyrosine benzyl ester, N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]tyrosine benzyl ester is obtained in a 78% yield in the form of a white solid, having the following characteristics: Rf =0.16 [hexane/ethyl acetate (65:35 by volume)].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05801274 |
| 出典データセット | uspto-grants-1998_09 |
| ORD ID | ord-a0498eba4daa4d7b8e491eda8464d61e |
| 出典メモ | uspto-grants-1998_09 |