Potassium Carbonate → HCID 18977778, compound

Participants

Reaction Conditions

Reaction Steps

42.0 g (0.14 mol) of 2-(4-hydroxyphenyl)-5-octylpyrimidine are dissolved in 400 ml of DMF, and 38.7 g (0.28 mol) of K2CO3 and 36.0 g (0.21 mol) of 8-chlorooctan-1-ol are added. The mixture is subsequently heated at 100° C. with monitoring by TLC until the reaction is complete. The mixture is poured into 3 l of ice water, and the precipitated product is filtered off with suction, washed with water, dried under reduced pressure and recrystallized from cyclohexane.

Provenance & Evidence