Water → HCID 22735140, compound

Participants

Reaction Steps

A suspension of 4-[4-chloro-2-(methylsulphonyl)benzoyl]-5-cyclopropylisoxazole (2.2 g) in ethanol was added to a solution of sodium ethoxide in ethanol (prepared from sodium (0.2 g) and ethanol). The mixture was stirred at room temperature for 2 hours then poured into water and acidified to pH 1. It was extracted with ethyl acetate, washed with water, dried (MgSO4) and filtered. The filtrate was evaporated to dryness and the residue was recrystallised from ethyl acetate and cyclohexane to give 1-[4-chloro-2-(methylsulphonyl)phenyl]-2-cyano-3-cyclopropylpropan-1,3-dione, COMPOUND 612, (1.7 g) as a light brown solid, m.p. 116° C.

Provenance & Evidence