Ethanol → HCID 18978029, compound

Participants

Reaction Steps

2-Cyclohexylsulphenyl-4-trifluoromethylbenzonitrile (10.55 g) was added to a mixture of sodium hydroxide (52.75 g) in aqueous ethanol and the resultant mixture was stirred and heated at reflux for 23 hours. It was cooled, diluted with water and filtered. The filtrate was acidified and extracted with dichloromethane, washed with water, dried (MgSO4) and filtered to give 2-cyclohexylsulphenyl-4-trifluoromethylbenzoic acid (10.7 g) as an off-white solid m.p. 115.4°-116.4° C.

Provenance & Evidence