Hydroxyamine hydrochloride → HCID 53690474, compound

Participants

Reaction Steps

A mixture of 3-cyclopropyl-2-(N,N-dimethylaminomethylene)-1-[2-(1-methylpropylsulphenyl)-4-trifluoromethylphenyl]propan-1,3-dione (11.9 g) and hydroxylamine hydrochloride (2.3 g) in ethanol was stirred at room temperature overnight. The mixture was cooled (ice bath) and a solid filtered off, washed with a small amount of cold ethanol, then water, and dried to give 5-cyclopropyl-4-[2-(1-methylpropylsulphenyl)-4-trifluoromethylbenzoyl]isoxazole (3.8 g) as a white solid, m.p. 75.6°-76.4° C.

Provenance & Evidence