p-Toluenesulfonic acid → HCID 18977980, compound

Participants

Reaction Steps

A mixture of crude t-butyl 2-[2-chloro-4-(methylsulphonyl)benzoyl]-3-oxopentanoate (12.0 g) and 4-toluenesulphonic acid (0.1 g) in toluene was stirred and heated at reflux for 3.5 hours. After cooling, the mixture was washed with water, dried (MgSO4) and filtered. The filtrate was evaporated to dryness and the residue was triturated with ether and filtered to give 1-[2-chloro-4-(methylsulphonyl)phenyl]pentan-1,3-dione (7.02 g) as a white solid NMR(CDCl3): 1.2(t,3H) 2.45 (q,2H) 3.0(s,3H) 5.9(s,1H) 7.5-8.0(m,3H).

Provenance & Evidence