Chloroacetic Acid → HCID 135703296, compound

Participants

Reaction Steps

A solution of 0.4 g of 2-amino-6-butyl-5-[(2'-methoxycarbonylbiphenyl-4-yl)methyl]pyrimidin-4-one in, 10 ml of anhydrous DMF is added in succession with 0.1 g of chloroacetic acid, 0.21 g of DCC and 0.17 g of HOBT. After 8 h under magnetic stirring, the resulting solid is filtered off and the solvent is evaporated under reduced pressure. The residue is taken up with H2O and extracted with AcOEt. The organic phase is dried over Na2 SO4 and evaporated under reduced pressure to obtain 0.47 g of a yellowish spongy solid which can be reacted without further purification.

Provenance & Evidence