Sodium Hydroxide → HCID 18978978, compound

Participants

Reaction Steps

A solution of 0.17 g of 5-butyl-6-[(2'-methoxycarbonylbiphenyl-4-yl)methyl]imidazo[1,2-a]pyrimidin-2,7-dione in 2 ml of MeOH is added with 32 mg of NaOH dissolved in 0.05 ml of H2O. After 24 h under reflux, the solvent is evaporated under reduced pressure and the residue is taken up in H2O and acidified to pH 5, to separate a solid which is filtered off and washed thoroughly with H2O. The purification is carried out by FC (eluent CH2Cl2 --MeOH--AcOH 89:10:1), to obtain 85 mg of a white solid (51% yield; m.p.=220°-222° C.).

Provenance & Evidence