Chloroacetone → HCID 67695651, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 0.3 g of 2-amino-6-butyl-5-[(2'-methoxycarbonylbiphenyl-4-yl) methyl]pyrimidin-4-one in 6 ml of DMF is added under stirring with 61 μl of chloroacetone. After 18 h under stirring at 100° C., the solvent is evaporated under reduced pressure. The residue is taken up into water to separate a solid which is filtered and purified by FC (eluent CH2Cl2 --CH3OH 97:3), to obtain 90 mg of a spongy solid (27% yield).

Provenance & Evidence