Acetic Anhydride → HCID 131720814, compound

Participants

Reaction Steps

Then, the secondary hydroxyl group of monoprotected betulin compound 4 was acetylated using acetic anhydride in pyridine (Ac2O/pyridine), to yield monoprotected betulin acetate compound 5 of scheme 2 in 87% yield. Other acetylating agents also can be used. Examples of other acetylating agents include, but are not limited to, acetyl chloride; pentafluorophenyl acetate, triethylamine, and dimethylformamide; acetic anhydride, boron trifluoride etherate, and tetrahydrofuran; ketene, potassium tert-butoxide, and tetrahydrofuran; and acetic acid and trimethylsilyl chloride.

Provenance & Evidence