Bromine → HCID 18979096, compound

Participants

Reaction Conditions

Reaction Steps

Bromine (0.48 ml) was added dropwise to a solution of 7-fluoro-8-methoxyquinoline (1.6 g) in glacial acetic acid (24 ml). The mixture was heated to 40° C. for 4 h and the reaction quenched with 5% aqueous sodium metabisulphite (100 ml). The solution was basified with 25% aqueous sodium hydroxide to pH13 and the product extracted with ethyl acetate (3×150 ml). The extracts were combined, dried over magnesium sulphate, filtered and the filtrate evaporated in vacuo. The residue was purified by column chromatography on silica gel eluting with 25% ethyl acetate in hexane to yield the desired product as a white solid (0.50 g).

Provenance & Evidence