tert-Butanol → HCID 18979069, compound

Participants

Reaction Conditions

Reaction Steps

5-Bromo-8-methoxyquinoline-2-carboxylic acid (2 g), t-butanol (25 ml) and triethylamine (1.48 ml) were combined under a nitrogen atmosphere and heated to 80° C. Diphenylphosphorylazide (2.29 ml) was added to the solution and heating was continued for 60 h by which time a white preciptate was present. The reaction mixture was evaporated in vacuo onto silica and purified by flash chromatography to give the title compound (1.21 g) as an off white solid.

Provenance & Evidence