Hydrochloric Acid → HCID 362692, compound

Participants

Reaction Steps

To a suspension of 3 mmol of 2(R)-[(4-methoxybenzenesulfonyl)amino]-2-phenyl acetic acid methyl ester in 15 mL of ethanol is added 5 mL of aqueous 2.5M sodium hydroxide. The solid suspension dissolved, and is allowed to stir, stoppered, at ambient temperature overnight. The resulting suspension is acidified with aqueous 10% HCl and extracted with ethyl acetate, adding brine to facilitate phase separation. The organic phase is washed with water and with brine and dried over sodium sulfate. It is concentrated to afford 0.95 g (quantitative yield) of a white solid.

Provenance & Evidence