HRID2393149

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8000

Ethane, 1,1'-oxybis-, compd. with trifluoroborane (1:1)

C4H10BF3O

HCID12052

Silane, triethyl-

C6H16Si

结构：COCCOCN(c1onc(C)c1Cl)S(=O)(=O)c1c(C(OC(C)=O)c2cc3c(cc2CCOC(C)=O)OCO3)sc2ncccc12

HCID18614042

未命名化合物

PRODUCTS

生成物

结构：COCCOCN(c1onc(C)c1Cl)S(=O)(=O)c1c(Cc2cc3c(cc2CCOC(C)=O)OCO3)sc2ncccc12

HCID18614040

未命名化合物

收率 99%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The title compound was prepared by the method of Example 5(A) using N-(4-chloro-3-methyl-5-isoxazolyl)-N-(methoxyethoxymethyl)-2-{α-acetoxy-2-[2-(acetoxy)ethyl]-4,5-(methylenedioxy)benzyl}thieno[2,3-b]-pyridine-3-sulfonamide (0.1 3 g, 0.19 mmoles), CH2Cl2 (3 ml), triethylsilane (0.30 ml, 1.9 mmoles) and boron trifluoride etherate (0.12 ml, 0.95 mmoles), giving 0.12 g (96%) of the title compound as a yellow oil.

WORKUP

后处理

customThe title compound was prepared by the method of Example 5(A)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3cfcedf77c874c5d9bd1895a47307917
来源数据集: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05804585
来源说明: uspto-grants-1998_09

反应 SMILES

[Cl:1][C:2]1[C:3]([CH3:46])=[N:4][O:5][C:6]=1[N:7]([CH2:40][O:41][CH2:42][CH2:43][O:44][CH3:45])[S:8]([C:11]1[C:19]2[C:14](=[N:15][CH:16]=[CH:17][CH:18]=2)[S:13][C:12]=1[CH:20](OC(=O)C)[C:21]1[CH:26]=[C:25]2[O:27][CH2:28][O:29][C:24]2=[CH:23][C:22]=1[CH2:30][CH2:31][O:32][C:33](=[O:35])[CH3:34])(=[O:10])=[O:9].C([SiH](CC)CC)C.B(F)(F)F.CCOCC>C(Cl)Cl>[Cl:1][C:2]1[C:3]([CH3:46])=[N:4][O:5][C:6]=1[N:7]([CH2:40][O:41][CH2:42][CH2:43][O:44][CH3:45])[S:8]([C:11]1[C:19]2[C:14](=[N:15][CH:16]=[CH:17][CH:18]=2)[S:13][C:12]=1[CH2:20][C:21]1[CH:26]=[C:25]2[O:27][CH2:28][O:29][C:24]2=[CH:23][C:22]=1[CH2:30][CH2:31][O:32][C:33](=[O:35])[CH3:34])(=[O:9])=[O:10]