反应详情

Ethyl 6-amino-6-(2-naphthyl)hexanoate Ethyl 6-hydroxyimino-6-(2-naphthyl)hexanoate (19.2 g) and platinum oxide (0.96 g) were suspended in acetic acid (160 ml) and the suspension was stirred in a hydrogen atmosphere at room temperature for 10 hours. The catalyst was then filtered off and the filtrate was concentrated. The residue was dispersed in saturated aqueous sodium hydrogen carbonate solution and extracted with ethyl acetate. This extract was dried over anhydrous sodium sulfate and concentrated. The crude residue thus obtained was purified by silica gel column chromatography (ethyl acetate-methanol=10:1) to provide ethyl 6-amino-6-(2-naphthyl)hexanoate (12.1 g).

1. filtrationThe catalyst was then filtered off
2. concentrationthe filtrate was concentrated
3. additionThe residue was dispersed in saturated aqueous sodium hydrogen carbonate solution
4. extractionextracted with ethyl acetate
5. dry with materialThis extract was dried over anhydrous sodium sulfate
6. concentrationconcentrated
7. customThe crude residue thus obtained
8. customwas purified by silica gel column chromatography (ethyl acetate-methanol=10:1)