Benzoyl chloride → HCID 18979261, compound

Participants

Reaction Steps

While a solution (5 ml) of ethyl 6-amino-6-(2-naphthyl)hexanoate in acetonitrile (1.0 g) and a 1N aqueous solution of sodium hydroxide (4 ml) were vigorously stirred together under ice-cooling, benzoyl chloride (0.54 g) was added dropwise and the mixture was further stirred at room temperature for 1 hour. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The extract and the organic layer were combined, dried, and concentrated to provide ethyl 6-benzoylamino-6-(2-naphthyl)hexanoate (1.5 g).

Provenance & Evidence