HCID 18979130, compound → HCID 18979236, compound

HRID 2393180Notes

Reaction equation

HRID 2393180 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20]COC)=O.[NH2:24][OH:25].CO>[Cl-].[NH4+]>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([NH:24][OH:25])=[O:20]

Participants

4

Reactant 2

HCID 18979130HCID 18979130, compoundHCID 86645014HCID 86645014, compound

Product 1

HCID 18979236HCID 18979236, compound

Reagents, catalysts & solvents 1

HCID 25517Ammonium ChlorideSolvent

Procedure

The methoxymethyl 7-(1-amino-2-naphthyl)heptanoate (0.3 g) was added to 1M hydroxylamine/methanol (2.85 ml) and the mixture was stirred at room temperature for 1.5 hours. This reaction mixture was poured in saturated aqueous ammonium chloride solution and extracted with ethyl acetate. The organic layer was washed with water, dried, and concentrated to dryness, and the residue was recrystallized from hexane-ether to provide the title compound (0.116 g).

Workup

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. customdried
  4. concentrationconcentrated to dryness
  5. customthe residue was recrystallized from hexane-ether

Sources & evidence

ORD record
ord-9b0415ea17bb4a90b9bd1176d9006b47
Source dataset
uspto-grants-1998_09
Patent number
US05804601

Reaction notes

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