Hydrochloric Acid → 2-Chloro-4-methanesulfonyl-3-dimethoxymethylbenzoic acid

HRID 2393245Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2393245
[Cl:1][C:2]1[C:11]([CH:12]([O:15][CH3:16])[O:13][CH3:14])=[C:10]([S:17]([CH3:20])(=[O:19])=[O:18])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[C:11]([CH:12]([O:15][CH3:16])[O:13][CH3:14])=[C:10]([S:17]([CH3:20])(=[O:19])=[O:18])[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18974776Methyl 2-chloro-4-methanesulfonyl-3-dimethoxymethylbenzoate

Produkt 1

HCID 189747752-Chloro-4-methanesulfonyl-3-dimethoxymethylbenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl 2-chloro-4-methanesulfonyl-3-dimethoxymethylbenzoate in an amount of 3.0 g (9.3 mmol) was dissolved in methanol in a volume of 30 ml, and to the resulting solution, was added 10% aqueous solution of sodium hydroxide in a volume of 20 ml, and then, the mixture was stirred for 1 hour at an ambient temperature. The reacted-mixture was then added with 1-N hydrochloric acid to make it acidic, and crystals precipitated were filtrated, washed with water and dried to obtain the objective compound in an amount of 2.5 g.

Aufarbeitung

  1. customcrystals precipitated
  2. filtrationwere filtrated
  3. washwashed with water
  4. customdried
  5. customto obtain the objective compound in an amount of 2.5 g

Quellen und Nachweise

ORD-Eintrag
ord-e750d272bdc6481593e9a9e0d7c33aa4
Quelldatensatz
uspto-grants-1998_09
Patentnummer
US05807806

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