Oxalyl chloride → Benzeneacetyl chloride, 2,4,6-tris(1-methylethyl)-

Participants

Reaction Steps

A mixture of 2,4,6-triisopropylphenylacetic acid (6.03 g, 0.023 mol), oxalyl chloride (20 mL), and dimethylformamide (3 drops) was stirred vigorously at room temperature and then allowed to stand overnight at room temperature. The reaction mixture was then concentrated to give the product as an off-white solid 6.5 g, 100%. This was used directly in the next step.

Provenance & Evidence