Potassium Carbonate → HCID 70279053, compound

Participants

Reaction Steps

A mixture of 1,6-dichloro-3-(4-fluorophenyl)-2,3-dihydro-1H-indene (28 g, 0.1 mol), 2,2-dimethylpiperazine (15 g, 0.13 mol) and potassium carbonate (30 g) in acetone (250 mL) was refluxed for 18 h. The reaction mixture was evaporated in vacuo and treated with water and ether. The ether phase was separated and extracted with 1M methane sulfonic acid. The base was liberated with 10M sodium hydroxide, extracted with ether and dried (MgSO4). After filtration and evaporation in vacuo the residue was dissolved in acetone and treated with fumaric acid. The fumarate salt was filtered to give 27 g of 1 as the hemifumarate salt, mp 240°-241° C. A sample recrystallized from ethanol had mp 242°-244° C. Isomeric purity (TLC): 95% trans isomer (racemate).

Provenance & Evidence