HCID 13920592, compound → 8-Chloro-3-methoxy-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

HRID 2393281Notes

Reaction equation

HRID 2393281 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:17](=O)[C:10]3=[N:11][CH:12]=[C:13]([O:15][CH3:16])[CH:14]=[C:9]3[CH2:8][CH2:7][C:6]=2[CH:19]=1.FC1C=CC2CC[C:27]3[C:28](C(=O)C=2C=1)=[N:29][CH:30]=[CH:31][CH:32]=3>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:17](=[C:32]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)[C:10]3=[N:11][CH:12]=[C:13]([O:15][CH3:16])[CH:14]=[C:9]3[CH2:8][CH2:7][C:6]=2[CH:19]=1

Participants

3

Reactant 2

HCID 13920592HCID 13920592, compoundHCID 183827268-Chloro-3-methoxy-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Product 1

HCID 183827248-Chloro-3-methoxy-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Procedure

By substituting in Preparative Example 2 step D, 8-chloro-3-methoxy-5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-one for 9-fluoro-5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-one and employing basically the same methods as steps D through H of Preparative Example 2, one obtains 8-chloro-3-methoxy-11-(4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b]pyridine as a white solid (MH+ 340).

Sources & evidence

ORD record
ord-1917d96064c64439b12c0560f7ce9169
Source dataset
uspto-grants-1998_09
Patent number
US05807853

Reaction notes

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