Hydrochloric Acid → HCID 67662987, compound

Participants

Reaction Steps

Ethyl acetate (175 ml) was added to N-{5-(1-imidazolyl)-2-methoxyphenyl}methyl-N-(1-pentyl)-N'-[2-{3-(4-phenyl-1-piperazinyl)propoxy}-6-methylphenyl]urea (11.7 g, 0.0187 mol). The mixture was added dropwise with 4N HCl solution in ethyl acetate (16 ml, 0.064 mol) at room temperature with stirring. After stirred for 1 hour at room temperature, the mixture was added with ether (100 ml), and stirring was continued for 1 hour at room temperature. The precipitated amorphous crystals were collected by filtration under nitrogen atmosphere and dried at 60° C. under reduced pressure to give N-{5-(1-imidazolyl)-2-methoxyphenyl}methyl-N-(1-pentyl)-N'-[2-{3-(4-phenyl-1-piperazinyl)propoxy}-6-methyphenyl]urea trihydrochloride. (13.15 g).

Provenance & Evidence