Acetone → HCID 9853085, compound

Participants

Reaction Steps

Acetone (84 ml) and water (8.4 ml) were added to N-{5-(1-imidazolyl)-2-methoxyphenyl}methyl-N-(1-pentyl)-N'-[2-{3-(4-phenyl-1-piperazinyl)propoxy}-6-methylphenyl]urea (5.0 g, 8.0 mmol). The mixture was added dropwise with concentrated hydrochloric acid (1.5 ml, 17 mmol) with stirring at room temperature, and then added with seed crystals. After stirring for 3 hours under ice cooling, the precipitated crystals were collected by filtration and dried at 60° C. under reduced pressure to give N-{5-(1-imidazolyl)-2-methoxyphenyl}methyl-N-(1-pentyl)-N'-[2-{3-(4-phenyl-1-piperazinyl)propoxy}-6-methylphenyl]urea dihydrochloride (5.1 g).

Provenance & Evidence