Triethylamine → HCID 18975633, compound

Participants

Reaction Steps

A mixture of the 3-allylaminopropionic acid (21.9 g), 2,6-dimethylphenyl-isothiocyanate (19 g), triethylamine (20 g) and methylene chloride (200 mL) was heated at reflux for 3 hours. The cooled reaction mixture was extracted with 1N NaOH (150 mL). The aqueous layer was separated and acidified with 2N HCl. The solid was collected by filtration. 13.5 g of the title compound was obtained and used without further purification for the reaction in step 3.

Provenance & Evidence