Ethanol → HCID 18974894, compound

Participants

Reaction Conditions

Reaction Steps

4-Bromoacetyl-6-(4-chlorophenyl)-1-methyl-4H-2,3,4,5,10b-pentaazabenz[e]azulene (8 mg) obtained in Example 171 was suspended in ethanol and 2-anisidine (12.5 μl) was added. The mixture was stirred at 80° C. for 3 hours. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. Water (20 ml) was added to the residue and the mixture was extracted with ethyl acetate (20 ml). The organic layer was further washed with water, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by preparative thin-layer chromatography to give 2.4 mg of the title compound as an oil.

Provenance & Evidence