HCID 18975435, compound → HCID 70202500, compound

Participants

Reaction Steps

5.85 g of 10-(1-tert-butoxycarbonyl-1-hydroxymethyl)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one are heated to 90°-100° C. in 300 ml of dimethylformamide, filtered immediately and 150 ml of methanol and 200 ml of water are added to the filtrate, which is left overnight at a temperature in the region of 5° C. The crystals formed are filtered off, washed with 20 ml of water and dried at 80° C. under vacuum (2 mmHg; 0.26 kPa) to give 3.4 g of 10-(tert-butoxycarbonylmethylene)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one in the form of a red solid melting above 260° C. (Analysis, % calculated C: 68.05, H: 5.11, N: 12.53, O: 14.31, % found C: 68.0, H: 5.6, N: 12.5, O: 14.3).

Provenance & Evidence