HCID 56988602, compound → HCID 18975407, compound

Participants

Reaction Steps

A solution of 19.95 g of 10-(carboxymethyl-ene)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one in 720 ml of 1N sodium hydroxide and 200 ml of water is hydrogenated at 1.7 bar and at a temperature in the region of 23° C. for 22 hours in the presence of 2 g of 10% palladium-on-charcoal. The reaction mixture is filtered and the filtrate is acidified with 95 ml of 1N hydrochloric acid. The precipitate formed is filtered off, washed with water (200 ml), then with acetone (5×200 ml) and dried at 80° C. under vacuum (1 mmHg; 0.13 kPa). 17.65 g of 10-(carboxymethyl)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one are obtained in the form of a light-grey solid, which product is converted into the sodium salt of formula C15H10N3O3Na (Analysis, % calculated C: 59.41, H: 3.32, N: 13.86, O: 15.83, Na: 7.58, % found C: 59.3, H: 2.9, N: 13.7).

Provenance & Evidence