HCID 70205854, compound → HCID 18975410, compound

Participants

Reaction Steps

3 g of 10-(3-nitrobenzylidene)-5H-imidazo-(1,2-a]indeno[1,2-e]pyrazin-4-one are hydrogenated at atmospheric pressure and at 50° C. in the presence of 10% palladium-on-charcoal in 100 ml of dimethylformamide. After 20 hours of reaction, the reaction medium is filtered on Celite. The insoluble material is washed with 1 liter of dimethyl sulphoxide and the filtrate is concentrated to dryness under reduced pressure. After drying of the yellow powder thus obtained (5 mmHg; 0.65 kPa) at 65° C., 2.5 g of 10-(3-aminobenzyl)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one are obtained, the melting point of which is greater than 260° C. (Analysis, C20H16N4O.0.52 H2O.0.30 DMSO; % calculated C: 73.16; H: 4.91; N: 17.06; % found C: 73.2; H: 5.1; N: 17.2).

Provenance & Evidence