Chlorotrimethylsilane → 10-hydroxymethyl-10-methyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one

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Reaction Steps

The process is performed as in Example 50 for the preparation of ethyl 5-(10-methyl-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-10-yl)-valerate but starting with 0.48 g of 10-methyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one, 25 ml of dimethylformamide, 0.33 g of sodium hydride, 0.28 ml of trimethylsilyl chloride and 0.1 g of trioxane. 0.27 g of 10-hydroxymethyl-10-methyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one is obtained in the form of a pale yellow solid melting above 260° C. (Analysis, % calculated C: 67.41, H: 4.90, N: 15.72, O: 11.97, % found C: 67.4, H: 4.9, N: 15.7).

Provenance & Evidence