HCID 67655264, compound → HCID 18975315, compound

Participants

Reaction Steps

Ethyl-3-(5-(1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)prop-2-enoate (0.5 g, 1.8 mmol) was hydrogenated over palladium on carbon (10%, 0.2 g) in methanol (75 mL) at 45 psi of hydrogen for 90 min. The catalyst was removed by filtration and the solvent evaporated in vacuo to give the title compound (0.455 g, 90%) as a colourless solid. mp 129°-131° C. 1H NMR (360 MHz, CDCl3) δ 1.24 (3H, t, J=7.1Hz), 2.72 (2H, t, J=7.4Hz), 3.13 (2H, t, J=7.4Hz), 4.14 (2H, q, J=7.1Hz), 7.31 (1H, d, J=2.3Hz), 8.08 (1H, s), 8.11 (1H, s), 8.54-8.60 (2H, m) and 9.15 (1H, s).

Provenance & Evidence