Hydrochloric Acid → HCID 57310684, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 3-(5-(1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)propionate (0.43 g, 1.5 mmol) in methanol (20 mL) was added NaOH (4M, 1 mL) and the mixture was heated at 50° C. for 5 hours. After cooling the solution was neutralised (5M, HCl) and the solvents evaporated in vacuo to give 3-(5-(1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)propionic acid (0.65 g) as a colourless solid. 1H NMR (360 MHz, d6 -DMSO) δ 2.60 (2H, t, J=7.5Hz), 2.98 (2H, t, J=7.4Hz), 7.55 (1H, s), 7.98 (1H, s), 8.23 (1H, s), 8.62 (1H, s), 9.24 (1H, s) and 11.74 (1H, br s). This was used without purification in the next step.

Provenance & Evidence