Acetic Anhydride → N-(4-methyl-5-nitropyridin-2-yl)acetamide

Participants

Reaction Steps

2-Amino-4-methyl-5-nitropyridine (28.4 g, 0.185 mol) was heated at 90° C. in acetic anhydride (100 mL) for 3 hours. After cooling the solvent was evaporated in vacuo and the residue was azeotroped with toluene to give a yellow solid. This was triturated with ether and the solid was collected by filtration to give the title compound (33.8 g, 93%) as a pale yellow solid. mp 153°-154° C. 1H NMR (360 MHz, CDCl3) δ 2.27 (3H, s), 2.70 (3H, s), 8.17 (1H, br s), 8.24 (1H, s) and 8.96 (1H, s).

Provenance & Evidence