Hydrochloric Acid → HCID 18975307, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 3-(5-(1,2,4-triazol-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)propionate (0.115 g, 0.4 mmol) in methanol (5 mL) was added NaOH (4M, 0.5 mL, 2 mmol) and the mixture heated at 40° C. for 16 hours. After cooling the solution was neutralised (5M HCl) and the solvents evaporated to give 3-(5-(1,2,4-triazol-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)propionic acid (0.23 g) as a colourless solid. 1H NMR (360 MHz, d6 -DMSO) δ 2.48-2.55 (2H, m), 2.96 (2H, t, J=7.1Hz), 7.54 (1H, s), 8.03 (1H, s), 8.62 (1H, s), 9.24 (2H, s) and 11.81 (1H, br s). This was used without further purification in the next step.

Provenance & Evidence