Hydrochloric Acid → HCID 18975689, compound

Participants

Reaction Steps

Cyclobutanecarbonyl chloride (5.5 g) was added to a solution of 2-(4-methoxyphenyl)ethylamine (7 g) and triethylamine (6.5 ml) in ether (300 ml), at ambient temperature. The mixture was stirred overnight, poured onto water and acidified with 2M hydrochloric acid, then the product was extracted with ethyl acetate (3×100 ml). The combined extracts were washed with brine, dried and the solvents removed in vacuo to give a residue. This was washed with light petroleum and dried in vacuo to give N-[2-(4-methoxyphenyl)ethyl]cyclobutanecarboxamide (9.54 g), mp 118°-120° C.

Provenance & Evidence