Diethyl Ether → Methyl (1,2-benzoxazol-3-yl)acetate

HRID 2393476Notes

Reaction equation

HRID 2393476 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][C:11]([OH:13])=[O:12])=[N:2]1.[CH3:14]COCC>CO>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:2]1

Participants

4

Reactant 2

HCID 3283Diethyl EtherHCID 3017292-(1,2-Benzoxazol-3-yl)acetic acid

Product 1

HCID 2763403Methyl (1,2-benzoxazol-3-yl)acetate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1,2-benzisoxazole-3-acetic acid (prepared according to G. Casini et al, J. Het. Chem. 6, 1969, 279) (18 g), ether saturated with dry HCI (150 ml) and methanol (200 ml) was stirred for 2 h at room temperature. Removal of the volatiles in vacuo gave methyl 1,2-benzisoxazole-3-acetate (17 g) as an oil.

Workup

  1. customRemoval of the volatiles in vacuo

Sources & evidence

ORD record
ord-db6d7adc09e14f29a3511edf5e8e5cf2
Source dataset
uspto-grants-1998_09
Patent number
US05807871

Reaction notes

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