Methanol → HCID 22012185, compound

HRID 2393477Notes

Reaction equation

HRID 2393477 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][C:12]#N)=[N:2]1.CC[O:16][CH2:17]C.C[OH:20]>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][C:12]([O:16][CH3:17])=[O:20])=[N:2]1

Participants

4

Reactant 3

HCID 887MethanolHCID 3283Diethyl EtherHCID 1227915159899-56-8

Product 1

HCID 22012185HCID 22012185, compound

Procedure

The nitrile was dissolved in methanol (200 ml) and HCI-saturated ether (200 ml) was added followed by stirring for 16 h at room temperature. The reaction mixture was concentrated in vacuo, water and ether added, and the phases separated. Drying of the ether phase over magnesium sulfate and removal of solvent in vacuo gave methyl 3-(1,2-benzisoxazol-3-yl)propionate (13 g) as an oil.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo, water and ether
  2. additionadded
  3. customthe phases separated
  4. dry with materialDrying of the ether phase over magnesium sulfate and removal of solvent in vacuo

Sources & evidence

ORD record
ord-1fe95c5ef52b4167b23aeae7c40ee946
Source dataset
uspto-grants-1998_09
Patent number
US05807871

Reaction notes

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