Hydrochloric Acid → HCID 11023487, compound

Participants

Reaction Conditions

Reaction Steps

1.5 g (4.78 mmoles) of the benzodiazepine derivative prepared in Step C are suspended in 60 ml of methanol, and to the suspension obtained, 4.64 g (57.3 mmoles) of concentrated hydrochloric acid are added, then, under cold water cooling, 2.07 g (54.8 mmoles) of sodium borohydride are added in portions. The suspension is stirred at 25° C. for 1 hour, then solid sodium carbonate is added to adjust the pH of the mixture to a value of about 8. The mixture is diluted with 60 ml of water, the product separated is filtered, washed 4 times using 5 ml of 50% aqueous methanol each time, and dried to obtain 1.47 g (97.4%) of the title compound. M.p.: 152°-154° C.

Provenance & Evidence