Methyl Isocyanate → HCID 18975131, compound

HRID 2393494Notes

Reaction equation

HRID 2393494 reaction equation
[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[CH2:6][CH:7]([CH3:20])[NH:8][N:9]=[C:10]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.[CH3:23][N:24]=[C:25]=[O:26]>C(O)C>[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[CH2:6][CH:7]([CH3:20])[N:8]([C:25](=[O:26])[NH:24][CH3:23])[N:9]=[C:10]([C:11]3[CH:12]=[CH:13][C:14]([N+:17]([O-:19])=[O:18])=[CH:15][CH:16]=3)[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 18975181HCID 18975181, compound

Product 1

HCID 18975131HCID 18975131, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.84 g (2.33 mmoles) of 8-bromo-4-methyl-1-(4-nitrophenyl)-4,5-dihydro-3H-2,3-benzodiazepine (prepared in Example 22, Step D) are reacted with methyl isocyanate according to the method of Example 3. The crude product is suspended in 5 ml of hot ethanol. After filtration and drying, 0.82 g (84%) of the title compound are obtained. M.p.: 197°-200° C.

Workup

  1. filtrationAfter filtration
  2. customdrying

Sources & evidence

ORD record
ord-d49cbbd90f594065bb0f1fdb8c23329a
Source dataset
uspto-grants-1998_09
Patent number
US05807851

Reaction notes

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