Potassium cyanate → HCID 18975148, compound

HRID 2393495Notes

Reaction equation

HRID 2393495 reaction equation
[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[CH2:6][CH:7]([CH3:20])[NH:8][N:9]=[C:10]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.[O-:23][C:24]#[N:25].[K+]>C(O)(=O)C>[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[CH2:6][CH:7]([CH3:20])[N:8]([C:24](=[O:23])[NH2:25])[N:9]=[C:10]([C:11]3[CH:12]=[CH:13][C:14]([N+:17]([O-:19])=[O:18])=[CH:15][CH:16]=3)[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 11378442Potassium cyanateHCID 18975181HCID 18975181, compound

Product 1

HCID 18975148HCID 18975148, compoundYield 77.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 1.80 g (5 mmoles) of 8-bromo-4-methyl-1-(4-nitrophenyl)-4,5-dihydro-3H-2,3-benzodiazepine in 10 ml of glacial acetic acid is treated with 0.53 g (6.5 mmoles) of potassium cyanate. After 1 hour, the solution is poured onto water, and the precipitated crystals are filtered. The crude product is suspended in 15 ml of hot ethanol. After filtration and drying, 1.56 g (77%) of the title compound are obtained. M.p.: 193°-203° C.

Workup

  1. additionthe solution is poured onto water
  2. filtrationthe precipitated crystals are filtered
  3. filtrationAfter filtration
  4. customdrying

Sources & evidence

ORD record
ord-af20f55681c74549a839d41e52e97e33
Source dataset
uspto-grants-1998_09
Patent number
US05807851

Reaction notes

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