Ethyl isocyanate → HCID 18975140, compound

HRID 2393497Notes

Reaction equation

HRID 2393497 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[CH2:6][CH:7]([CH3:20])[NH:8][N:9]=[C:10]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.[CH2:23]([N:25]=[C:26]=[O:27])[CH3:24]>C1(C)C=CC=CC=1>[CH2:23]([NH:25][C:26]([N:8]1[CH:7]([CH3:20])[CH2:6][C:5]2[CH:21]=[CH:22][C:2]([Cl:1])=[CH:3][C:4]=2[C:10]([C:11]2[CH:12]=[CH:13][C:14]([N+:17]([O-:19])=[O:18])=[CH:15][CH:16]=2)=[N:9]1)=[O:27])[CH3:24]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 18975135HCID 18975135, compound

Product 1

HCID 18975140HCID 18975140, compoundYield 69.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

0.6 g (1.9 mmoles) of 8-chloro-4-methyl-1-(4-nitrophenyl)-4,5-dihydro-3H-2,3-benzodiazepine (prepared in Example 5, Step D or in Example 36, starting compound) are boiled with 0.75 ml (9.5 mmoles) of ethyl isocyanate in 25 ml of anhydrous toluene for 24 hours. The mixture is evaporated, the residue is recrystallized from 5 ml of ethanol. Thus, 0.51 g (69%) of the title compound are obtained. M.p.: 170°-172° C.

Workup

  1. customThe mixture is evaporated
  2. customthe residue is recrystallized from 5 ml of ethanol

Sources & evidence

ORD record
ord-def671a41118478682464f29d61b7221
Source dataset
uspto-grants-1998_09
Patent number
US05807851

Reaction notes

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