Propyl isocyanate → HCID 18975159, compound

HRID 2393498Notes

Reaction equation

HRID 2393498 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[CH2:6][CH:7]([CH3:20])[NH:8][N:9]=[C:10]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.[CH2:23]([N:26]=[C:27]=[O:28])[CH2:24][CH3:25]>>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[CH2:6][CH:7]([CH3:20])[N:8]([C:27](=[O:28])[NH:26][CH2:23][CH2:24][CH3:25])[N:9]=[C:10]([C:11]3[CH:12]=[CH:13][C:14]([N+:17]([O-:19])=[O:18])=[CH:15][CH:16]=3)[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 61033Propyl isocyanateHCID 18975135HCID 18975135, compound

Product 1

HCID 18975159HCID 18975159, compoundYield 83%

Procedure

0.6 g (1.9 mmoles) of 8-chloro-4-methyl-1-(4-nitrophenyl)-4,5-dihydro-3H-2,3-benzodiazepine (prepared in Example 5, Step D or in Example 36, starting compound) are reacted with n-propyl isocyanate according to the method described in Example 44. The crude product is recrystallized from ethanol. Thus, 0.63 g (83%) of the title compound are obtained. M.p.: 186°-187° C.

Workup

  1. customThe crude product is recrystallized from ethanol

Sources & evidence

ORD record
ord-daa99267cb4d4daea6f43e6f131ca650
Source dataset
uspto-grants-1998_09
Patent number
US05807851

Reaction notes

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